- Professor
- Phone: 979-862-3099
- Email: chilty@chem.tamu.edu
- Office: CHEM 1231
- Hilty Research Group
- Web of Science Profile
- Analytical
- Chemical Biology
- Instrumentation
- Physical
- Polymer
- Spectroscopy & Dynamics
Research Interests
We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.
To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments, and investigate the dynamics of hyperpolarized spin systems.
Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants of protein structure and function, including of membrane proteins.
Educational Background
- Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich
- Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich
- Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory
Awards & Honors
- Camille & Henry Dreyfus New Faculty Award 2006
- Raymond Andrew Prize (Ampere Society) 2005
Selected Publications
Qi, C., Wang, Y. and Hilty, C. Application of Relaxation Dispersion of Hyperpolarized 13C Spins to Protein-Ligand Binding. Angew. Chem. Int. Ed. 60(45): 24018-24021 (2021).
Mandal, R., Pham, P. and Hilty, C. Characterization of protein–ligand interactions by SABRE. Chem. Sci. 12(39): 12950-12958 (2021).
Kim, Y., Samouei, H. and Hilty, C. Polyolefin Catalysis of Propene, 1-Butene and Isobutene Monitored Using Hyperpolarized NMR. Chem. Sci. 12(8): 2823-2828 (2021).
Wang, Y., Kim, J. and Hilty, C. Determination of protein-ligand binding modes using fast multi-dimensional NMR with hyperpolarization. Chem. Sci. 11(23): 5935-5943 (2020).
Pham, P. and Hilty, C. Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates. Chem. Commun. 56(98): 15466-15469 (2020).